I’ve been waiting for this plugin or feature to surface to self-hosted WordPress sites. It’s a feature that has been available to WordPress.com users as long as I can remember. With this plugin, you will be able to add a network of blogs with different domains.
For example. Your primary domain is ‘example.com.’ You can create several blogs in a multi-site install of WordPress 3.0 using a different domains like ‘sample.com’ or ‘widgets.com.’
Download the plugin.